Emergency?Call 911·Poison Control: 1-800-222-1222·SAMHSA Helpline: 1-800-662-4357 (free, 24/7)

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Harm reduction information — no account, no tracking.

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  • Data from FDA, NIH, RxNav & SAMHSA
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Good Samaritan Laws

General summary

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    Drug Interaction Checker

    Enter up to 8 drugs or medications to check known interaction statements from FDA labels. Start typing to see RxNorm name suggestions. This is a safety reference, not a substitute for clinical advice.

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    Medication Lookup

    Search by medication name or scan/enter a barcode to see active ingredients, warnings, contraindications, and FDA recall status.

    Find Help & Harm Reduction Resources

    Verified hotlines, text services, and online locators for treatment centers, naloxone access, and syringe services. All resources are free and confidential.

    SAMHSA National Helpline

    24/7 · Free · Confidential

    Free, confidential, 24/7 treatment referral and information service in English and Spanish.

    Call 1-800-662-4357

    988 Suicide & Crisis Lifeline

    24/7 · Free

    Call or text 988 for mental health and substance use crisis support.

    Call or Text 988

    Crisis Text Line

    24/7 · Free

    Text HOME to 741741 for free, 24/7 crisis support via text message.

    Text HOME to 741741

    Text your ZIP for treatment locations

    SAMHSA

    SAMHSA text service: text your 5-digit ZIP code to 435748 (HELP4U) to receive nearby treatment center information.

    Text ZIP to HELP4U (435748)

    FindTreatment.gov

    Official · SAMHSA

    SAMHSA's official treatment locator — search by address for nearby treatment centers, mental health services, and more.

    Open FindTreatment.gov

    NEXT Distro — Naloxone & Harm Reduction

    Mail-order naloxone and harm reduction supplies. Available in participating states.

    Visit NEXT Distro

    NASEN — Syringe Services Near You

    Directory of syringe service programs across the US maintained by the National Alliance of Syringe Service Programs.

    Find syringe services

    Narcan availability at pharmacies

    Naloxone (Narcan) is available without a prescription at most CVS, Walgreens, and Rite Aid locations. Show the pharmacist — no Rx needed in most states.

    Find CVS pharmacy

    This is a safety reference. In an emergency, call 911. Data sourced from SAMHSA, NASEN, and NEXT Distro — verify availability in your area.

    Safety Guides & Overdose Response

    Practical, plain-language safety guides written by and for the community — reviewed against public health references. Includes overdose signs and step-by-step first aid.

    Safer Use Basics

    Start low, go slow, and avoid using alone. Potency varies heavily in unregulated supply chains.

    • Test a very small amount first and wait before re-dosing.
    • Avoid mixing depressants (opioids, benzos, alcohol) because respiratory risk compounds quickly.
    • Use with a trusted person whenever possible and establish a check-in plan.

    Sources: WHO, NIDA

    Fentanyl Contamination Risk

    Counterfeit pills and non-opioid powders can contain fentanyl. Treat unknown supply as high risk.

    • Use fentanyl test strips where legal and available.
    • Keep naloxone accessible before any use event.
    • If someone becomes very sleepy or breathing slows, treat it as a possible opioid overdose immediately.

    Sources: NIDA, CDC

    When to Seek Help

    If breathing is slow, stopped, or irregular, call emergency services right away and give naloxone if available.

    • Call emergency services and stay with the person.
    • Give naloxone and repeat per kit instructions if no response.
    • Place in recovery position if breathing returns but they remain unconscious.

    Sources: CDC, SAMHSA

    Overdose Signs & First Aid

    Universal First Aid Protocol — DRABC

    1. DDanger
    2. RResponse
    3. AAirway
    4. BBreathing
    5. CCirculation

    Opioids

    Life-Threatening Emergency3RsRecognize · Respond · Reverse
    • Slow or stopped breathing
    • Blue or gray lips / fingertips
    • Pinpoint pupils
    • Unresponsive to voice or touch
    1. 1Call 911 immediately.
    2. 2Give naloxone — nasal spray or injection per kit instructions.
    3. 3Rescue breathe: 1 breath every 5 seconds.
    4. 4Repeat naloxone in 2–3 min if no response.

    Stimulants

    Medical Emergency
    • Chest pain or racing heart
    • Seizure
    • Very high body temperature
    • Severe agitation or confusion
    1. 1Call 911 immediately.
    2. 2Move to a cool, quiet area — reduce stimulation.
    3. 3Do not restrain; protect from injury during seizure.

    Alcohol / Benzos

    Life-Threatening Emergency
    • Very slow or stopped breathing
    • Vomiting while unconscious
    • Cannot be woken
    • Clammy or cold skin
    1. 1Call 911 immediately.
    2. 2Place in recovery position — on their side, chin forward.
    3. 3Never leave the person alone.

    Sources & References

    All content on this site is drawn from the following public health and clinical references, checked for accuracy.